John Leavitt at the Pauling Institute in Palo Alto CA in the 1980′s (left), Becki at the Pauling Institute in January 1987 (middle), and Linus Pauling and Ewan Cameron at the Pauling Institute in the late 1980′s (right).
Link to “Gene Doping in Athletics – Prospects for the 21st Century”
Link to “Interfering RNA – An Investment hint for Woodstockians“
Since I recommended this stock, its price has risen from less than $15 to $34 per share.
Link to the “Garrett Ihler Story”
Link to Flu Hysteria…
Link to “Flu Mania”
Link to “Who Isolated the First Gene – the Garrett Ihler Story“
Link to “Human Embryonic Stem Cell Cloning – a Stunning Breakthough“
Link to “Human Embyronic Stem Cell Debate” – an interview with John Leavitt
Link to “The Stem Cell Debate at the Cafe“
Link to “Bird Flu in Perspective“
Link to “Prion Diseases“
Link to “Better Monkeys“
Link to “Ambition and Fraud in the Biosciences – Part 1“
Link to “Ambition and Fraud in the Biosciences – Part 2“
Link to “Ambition and Fraud in the Biosciences – Part 3“
EDUCATION
1961-1966 B.S. Chemistry & Math, Bethany College, Bethany WV
1966-1971 Ph.D. in Biochemistry, University of Pittsburgh School of Medicine
1971-1977 NIH-sponsored Post-Doctoral Fellow, Dept. of Biochemistry, Johns Hopkins University, Baltimore MD
EMPLOYMENT
1977-1982 Senior Fellow & Research Biochemist – Bureau of Biologics (CBER), FDA, NIH campus, Bethesda MD
1982-1988 Senior Scientist – Linus Pauling Institute, Palo Alto CA
1988-1991 Scientific Director – California Institute for Medical Research, San Jose CA.
1991-1993 Director of Research – Adeza Biomedical, Sunnyvale, CA.
1991-1996 Senior Scientist – Palo Alto Medical Foundation Research Institute, Palo Alto CA.
1994-1995 Adjunct Faculty – Dept. of Biology, US Air Force Academy, Colorado Springs CO
1996-pres Biotech Analyst – NERAC, Inc., Tolland CT.
FELLOWSHIPS – NIH Predoctoral Fellowship, Univ. Pittsburgh School of Medicine, 1966-1971; NIH Postdoctoral Fellowship, Johns Hopkins University, Dept. of Biochemistry, 1971-1973; Natl. Cancer Inst. Postdoctoral Fellowship, 1973-1976; Senior Staff Fellow, FDA, 1977-1979
FEDERAL GRANT & CONTRACT AWARDS ($2.4 million in funding)
March of Dimes Grant to John Leavitt to investigate gene transfer 1974-1976,
ACS-NP-433 to John Leavitt from the American Cancer Society “MUTANT Beta-ACTIN GENE STRUCTURE AND FUNCTION IN NEOPLASIA” Jan. 1st, 1984 to Dec 31st, 1986.
From CRISP (NIH grants):
R01CA034763-01-04 to John Leavitt from the Natl. Cancer Inst. “MUTANT Beta-ACTIN GENE STRUCTURE AND FUNCTION IN NEOPLASIA” June 15th, 1984 to Feb 29th, 1988.
RO1CA034763-05-07 to John Leavitt from the Natl. Cancer Inst. “ROLES OF MICROFILAMENT PROTEINS AND PLASTIN IN NEOPLASIA” March 1st 1988 to Nov. 30th 1990.
R01CA034763-08-10 to John LEAVITT from the Natl. Cancer Inst. “ROLES OF MICROFILAMENT PROTEINS IN NEOPLASIA/METASTASIS” May 1st 1991 to April 30th 1994.
R01CA049423-01 to John LEAVITT from the Natl. Cancer Inst. “ROLE OF METASCHEMATIN PROTEINS IN NEOPLASIA” May 10th 1989 to April 30th 1992. S07RR005768-10 John LEAVITT from the Natl. Ctr. Research Resources BIOMEDICAL RESEARCH SUPPORT GRANT April 1st 1988.
S07RR005768-11 John LEAVITT from the Natl. Ctr. Research Resources BIOMEDICAL RESEARCH SUPPORT GRANT April 1st 1989.
S07RR005768-12 John LEAVITT from the Natl. Ctr. Research Resources BIOMEDICAL RESEARCH SUPPORT GRANT April 1st 1990 .
S15AG008028-01 John LEAVITT from the Natl. Inst. on Aging Small Instrumentation Grant July 1st 1988.
S15CA053652-01 John LEAVITT from the Natl. Cancer Inst. Small Instrumentation Grant Aug 1st 1990.
Contract to John Leavitt from the Laser and Optics Research Center, US Airforce Academy, Sep 22nd 1994 to Sep 21, 1995.
FEDERAL PEER REVIEW STUDY SECTIONS (grant reviewing and approvals)
Army Breast Cancer Research Program (USAMRMC) study section 1993, NIH.
AdHoc SBIR study section 1987.
NIH Cytology Study Section 1989.
CONSULTANTSHIPS – Channing-Weinberg Venture Fund 1986.
Selected Peer-Reviewed Papers published by John Leavitt (>3500 citations of all 70 published papers as of Jan. 2001)
1. The use of the L-plastin promoter for adenoviral-mediated tumor-specific gene expression in ovarian and bladder cancer cell lines.
Peng, X. Y.; Crystal, R.; Leavitt, J. ; Deisseroth, A et al.
JOURNAL NAME- Cancer Research VOL. 61 2001 PP. 4405-13.
Corporate Author- Genetic Therapy Program,Yale Univ. Sch. Med., New Haven, CT 06520, USA
Citation references – 26
2. Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Chung, I.; Schwartz, P. E.; Crystal, R. G.; Pizzorno, G.; Leavitt, J. ; Deisseroth, A. B.
JOURNAL NAME- Cancer Gene Therapy
VOL. 6 NO. 2 1999 Mar-Apr PP. 99-106 CORPORATE AUTHOR- Yale University School of Medicine, New Haven, Connecticut 06520 Citation references – 39
3. Mutagenic activity of high-energy 532 nm ultra-short laser pulses.
Leavitt, J. ; Fatone, M.; Hestdalen, C.; Obringer, J. W.; Tillinghast, H. S. Jr
JOURNAL NAME- Radiation Research
VOL. 147 NO. 4 1997 Apr PP. 490-4
CORPORATE AUTHOR- Department of Biology, United States Air Force Academy, Colorado Springs, Colorado 80840, USA. Citation references – 2
4. Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin.
Adams, A. E.; Shen, W.; Lin, C. S.; Leavitt, J. ; Matsudaira, P.
JOURNAL NAME- Mol Cell Biology
VOL. 15 NO. 1 1995 Jan PP. 69-75
CORPORATE AUTHOR- Department of Molecular and Cellular Biology, University of Arizona Tucson
Citation references – 22
5. Discovery and characterization of two novel human cancer-related proteins using two-dimensional gel electrophoresis.
Leavitt, J.
JOURNAL NAME- Electrophoresis
VOL. 15 NO. 3-4 1994 Mar-Apr PP. 345-57
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 16
6. Regulation of synthesis of the transformation-induced protein, leukocyte plastin, by ovarian steroid hormones.
Leavitt, J. ; Chen, Z. P.; Lockwood, C. J.; Schatz, F.
JOURNAL NAME- Cancer Research
VOL. 54 NO. 13 1994 Jul 1 PP. 3447-54
CORPORATE AUTHOR- CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301
Citation references – 5
7. Activation of the leukocyte plastin gene occurs in most human cancer cells.
Park, T.; Chen, Z. P.; Leavitt, J.
JOURNAL NAME- Cancer Research
VOL. 54 NO. 7 1994 Apr 1 PP. 1775-81
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 20
8. Characterization of the human L-plastin gene promoter in normal and neoplastic cells.
Lin, C. S.; Chen, Z. P.; Park, T.; Ghosh, K.; Leavitt, J.
JOURNAL NAME- J Biol Chemistry
VOL. 268 NO. 4 1993 Feb 5 PP. 2793-801
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 38
9. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.
Lin, C. S.; Park, T.; Chen, Z. P.; Leavitt, J.
JOURNAL NAME- J Biol Chemistry
VOL. 268 NO. 4 1993 Feb 5 PP. 2781-92
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 65
10. Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database.
Aebersold, R.; Leavitt, J.
JOURNAL NAME- Electrophoresis
VOL. 11 NO. 7 1990 Jul PP. 517-27
CORPORATE AUTHOR- Biomedical Research Centre, University of British Columbia, Vancouver, Canada.
Citation references – 54
11. Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins.
de Arruda, M. V.; Watson, S.; Lin, C. S.; Leavitt, J. ; Matsudaira, P.
JOURNAL NAME- J Cell Biology
VOL. 111 NO. 3 1990 Sep PP. 1069-79
CORPORATE AUTHOR- Whitehead Institute for Biomedical Research, MIT, Cambridge, Massachusetts.
Citation references – 102
12. Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.
Lin, C. S.; Aebersold, R. H.; Leavitt, J.
JOURNAL NAME- Mol Cell Biology
VOL. 10 NO. 4 1990 Apr PP. 1818-21
CORPORATE AUTHOR- California Institute for Medical Research, San Jose 95128.
Citation references – 35
13. Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.
Lin, C. S.; Leavitt, J.
JOURNAL NAME- Mol Cell Biology
VOL. 8 NO. 1 1988 Jan PP. 160-8
CORPORATE AUTHOR- Linus Pauling Institute of Science and Medicine, Palo Alto, California 94306 Citation references – 31
14. A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.
Gunning, P.; Leavitt, J. ; Muscat, G.; Ng, S. Y.; Kedes, L.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 84 NO. 14 1987 Jul PP. 4831-5
CORPORATE AUTHOR- Dept. of Medicine, Stanford University, CA
Citation references – 801
15. Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.
Lin, C. S.; Aebersold, R. H.; Kent, S. B.; Varma, M.; Leavitt, J.
JOURNAL NAME- Mol Cell Biology
VOL. 8 NO.11 1988 Nov PP. 4659-68
DOCUMENT TYPE- JOURNAL ARTICLE
CORPORATE AUTHOR- California Institute for Medical Research, San Jose, California 95128.
Citation references – 75
16. Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose.
Aebersold, R. H.; Leavitt, J. ; Saavedra, R. A.; Hood, L. E.; Kent, S. B.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 84 NO. 20 1987 Oct PP. 6970-4
DOCUMENT TYPE- JOURNAL ARTICLE
CORPORATE AUTHOR- Division of Biology, California Institute of Technology, Pasadena 91125.
Citation references – 745
17. Expression of transfected mutant beta-actin genes: transitions toward the stable tumorigenic state.
Leavitt, J. ; Ng, S. Y.; Varma, M.; Latter, G.; Burbeck, S.; Gunning, P.; Kedes, L.
JOURNAL NAME- Mol Cell Biology
VOL. 7 NO. 7 1987 Jul PP. 2467-76
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA
Citation references – 58
18. Expression of transfected mutant beta-actin genes: alterations of cell morphology and evidence for autoregulation in actin pools.
Leavitt, J. ; Ng, S. Y.; Aebi, U.; Varma, M.; Latter, G.; Burbeck, S.; Kedes, L.; Gunning, P.
JOURNAL NAME- Mol Cell Biology
VOL. 7 NO. 7 1987 Jul PP. 2457-66
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA
Citation references – 68
19. Tropomyosin isoform switching in tumorigenic human fibroblasts.
Leavitt, J. ; Latter, G.; Lutomski, L.; Goldstein, D.; Burbeck, S.
JOURNAL NAME- Mol Cell Biology
VOL. 6 NO. 7 1986 Jul PP. 2721-6 CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA
Citation references – 79
20. Identification and order of sequential mutations in beta-actin genes isolated from increasingly tumorigenic human fibroblast strains.
Lin, C. S.; Ng, S. Y.; Gunning, P.; Kedes, L.; Leavitt, J.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 82 NO. 20 1985 Oct PP. 6995-9 DOCUMENT TYPE- JOURNAL ARTICLE
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 28
21. Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.
Ng, S. Y.; Gunning, P.; Eddy, R.; Ponte, P.; Leavitt, J. ; Shows, T.; Kedes, L.
JOURNAL NAME- Mol Cell Biol
VOL. 5 NO. 10 1985 Oct PP. 2720-32
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 411
22. Abundant synthesis of the transformation-induced protein of neoplastic human fibroblasts, plastin, in normal lymphocytes.
Goldstein, D.; Djeu, J.; Latter, G.; Burbeck, S.; Leavitt, J.
JOURNAL NAME- Cancer Research
VOL. 45 NO. 11 Pt 2 1985 Nov PP. 5643-7
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 43
23. Smooth muscle alpha-actin is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells.
Leavitt, J. ; Gunning, P.; Kedes, L.; Jariwalla, R.
JOURNAL NAME- Nature
VOL. 316 NO. 6031 1985 Aug 29-Sep 4 PP. 840-2
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 114
24. Tumorigenic potential of human fibroblasts as a function of ability to express a novel form of influenza A nucleocapsid protein.
Leavitt, J.
JOURNAL NAME- Carcinogenesis
VOL. 4 NO. 10 1983 Oct PP. 1229-37
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 8
25. Molecular cloning and characterization of mutant and wild-type human beta-actin genes.
Leavitt, J. ; Gunning, P.; Porreca, P.; Ng, S. Y.; Lin, C. S.; Kedes, L.
JOURNAL NAME- Mol Cell Biology
VOL. 4 NO. 10 1984 Oct PP. 1961-9
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 113
26. Identification of polypeptides on two-dimensional electrophoresis gels by amino acid composition.
Latter, G. I.; Burbeck, S.; Fleming, J.; Leavitt, J.
JOURNAL NAME- Clinical Chemistry
VOL. 30 NO. 12 Pt 1 1984 Dec PP. 1925-32
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 34
27. Neoplastic human fibroblast proteins are related to epidermal growth factor precursor.
Burbeck, S.; Latter, G.; Metz, E.; Leavitt, J.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 81 NO. 17 1984 Sep PP. 5360-3
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 20
28. Variations in expression of mutant beta actin accompanying incremental increases in human fibroblast tumorigenicity.
Leavitt, J. ; Bushar, G.; Kakunaga, T.; Hamada, H.; Hirakawa, T.; Goldman, D.; Merril, C.
JOURNAL NAME- Cell
VOL. 28 NO. 2 1982 Feb PP. 259-68
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 92
29. Changes in gene expression accompanying chemically-induced malignant transformation of human fibroblasts.
Leavitt, J. ; Goldman, D.; Merril, C.; Kakunaga, T.
JOURNAL NAME- Carcinogenesis
VOL. 3 NO. 1 1982 PP. 61-70
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 37
30. Coexpression of a mutant beta-actin and the two normal beta- and gamma-cytoplasmic actins in a stably transformed human cell line.
Vandekerckhove, J.; Leavitt, J. ; Kakunaga, T.; Weber, K.
JOURNAL NAME- Cell
VOL. 22 NO. 3 1980 Dec PP. 893-9
DOCUMENT TYPE- Max-Planck Institute, Goettingen, Germany Citation references – 112
31. Dissimilar modes of expression of beta- and gamma-actin in normal and leukemic human T lymphocytes.
Leavitt, J. ; Leavitt, A.; Attallah, A. M.
JOURNAL NAME- J Biol Chemistry
VOL. 255 NO. 11 1980 Jun 10 PP. 4984-7
DOCUMENT TYPE- Bureau of Biologics, FDA, National Institutes of Health, Bethesda, MD
Citation references – 57
32. Expression of a variant form of actin and additional polypeptide changes following chemical-induced in vitro neoplastic transformation of human fibroblasts.
Leavitt, J. ; Kakunaga, T.
JOURNAL NAME- J Biol Chemistry
VOL. 255 NO. 4 1980 Feb 25 PP. 1650-61
DOCUMENT TYPE- Bureau of Biologics, FDA, National Institutes of Health, Bethesda, MD
Citation references – 130
THESIS – Doctor of Philosophy, Biochemistry “Stimulation of In-vitro RNA Synthesis by Ribosomes.” University of Pittsburgh, School of Medicine 1971. Sponsor – Kivie Moldave, Chairman of the Department of Biochemistry.
PRODUCTIVE COLLABORATIONS (leading to major papers) – Aaron Bendich, Memorial Sloan Kettering Inst. NY, Klaus Weber, Max-Planck Inst., Goettingen GR, Takeo Kakunaga, National Cancer Inst., Bethesda MD, Carl Merril, Natl. Inst. Mental Health, Bethesda MD, David Goldman, Natl. Inst. Mental Health, Bethesda MD, Larry Kedes & Peter Gunning, Stanford Univ., Brian Crawford, Los Alamos Natl. Laboratory, Ueli Aebi, Biozentrum, Univ. Basel, Reudi Aebersold & Lee Hood, California Inst. Technology, Paul Matsudaira, Whitehead Inst. MIT, Alison Adams, Univ. Arizona, Charles Lockwood & Fred Schatz, Mount Sinai Medical Center NY
PUBLISHED PATENTS
L-PLASTIN PROMOTER REGION AND ITS USES FOR REGULATING GENE EXPRESSION
INVENTOR(S) LEAVITT, JOHN C .
PCT INT. APPL., AUG 04 1994, 66 PP.
PATENT NUMBER- 94 17182
PATENT APPLICATION NUMBER- 94-US436
DATE FILED- JAN 25 1994
DOCUMENT TYPE- PATENT
PATENT ASSIGNEE(S)- RESEARCH INSTITUTE OF THE PALO ALTO MEDICAL FOUNDATION
PATENT APPLICATION PRIORITY- 930126US9167
DESCRIPTOR(S)- PLASTIN PROMOTER PROGESTERONE ESTROGEN GENE EXPRESSION
Plastin isoforms and their uses
INVENTOR(S)- Leavitt, John C .; Lin, Ching-Shwun; Aebersold, Ruedi H.
PATENT NUMBER- 05360715
PATENT APPLICATION NUMBER- 642983
DATE FILED- 1991-01-10
PATENT DATE- 1994-11-01
NUMBER OF CLAIMS- 16
PATENT CLASS- Invention (utility) patent
INVENTOR COUNTRY/ZIPCODE- .; .; CAX
PATENT ASSIGNEE(S)- California Institute of Technology
ASSIGNEE CITY- Pasadena CA
ATTORNEY, AGENT, OR FIRM- Skjerven, Morrill, MacPherson, Franklin & Friel
Plastin isoforms and their use
INVENTOR(S)- Leavitt, John C .; Lin, Ching-Shwun; Aebersold, Ruedi H.
PATENT NUMBER- 05002870
PATENT APPLICATION NUMBER- 495256
DATE FILED- 1990-03-16
PATENT DATE- 1991-03-26
NUMBER OF CLAIMS- 4
SUPPLEMENTARY NOTE(S)- 25611
PATENT CLASS- Invention (utility) patent
INVENTOR COUNTRY/ZIPCODE- .; .; CAX
PATENT ASSIGNEE(S)- California Institute for Medical Research
ASSIGNEE CITY- San Jose CA
ATTORNEY, AGENT, OR FIRM- Terlizzi, Laura
beta-Actin gene and regulatory elements, preparation and use.
INVENTOR(S)- Leavitt, J. C. ; Kedes, L. H.; Gunning, P. W.
PATENT NUMBER- EP 0174608
PATENT DATE- 1986 19 Mar
DOCUMENT TYPE- Patent
CORPORATE AUTHOR- Leland Stanford Junior University, USA
PATENT PRIORITY INFO- Appl. US 650958, filed 13 Sep 1984
PATENT TYPE- European Patent Appl.
ATTORNEY, AGENT, OR FIRM- Bert Rowland
(licensed to the Biotech Industry 1985-2002)
Peng, X. Y.; Crystal, R.; Leavitt, J. ; Deisseroth, A et al.
JOURNAL NAME- Cancer Research VOL. 61 2001 PP. 4405-13.
Corporate Author- Genetic Therapy Program,Yale Univ. Sch. Med., New Haven, CT 06520, USA
Citation references – 26
2. Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Chung, I.; Schwartz, P. E.; Crystal, R. G.; Pizzorno, G.; Leavitt, J. ; Deisseroth, A. B.
JOURNAL NAME- Cancer Gene Therapy
VOL. 6 NO. 2 1999 Mar-Apr PP. 99-106 CORPORATE AUTHOR- Yale University School of Medicine, New Haven, Connecticut 06520 Citation references – 39
3. Mutagenic activity of high-energy 532 nm ultra-short laser pulses.
Leavitt, J. ; Fatone, M.; Hestdalen, C.; Obringer, J. W.; Tillinghast, H. S. Jr
JOURNAL NAME- Radiation Research
VOL. 147 NO. 4 1997 Apr PP. 490-4
CORPORATE AUTHOR- Department of Biology, United States Air Force Academy, Colorado Springs, Colorado 80840, USA. Citation references – 2
4. Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin.
Adams, A. E.; Shen, W.; Lin, C. S.; Leavitt, J. ; Matsudaira, P.
JOURNAL NAME- Mol Cell Biology
VOL. 15 NO. 1 1995 Jan PP. 69-75
CORPORATE AUTHOR- Department of Molecular and Cellular Biology, University of Arizona Tucson
Citation references – 22
Leavitt, J.
JOURNAL NAME- Electrophoresis
VOL. 15 NO. 3-4 1994 Mar-Apr PP. 345-57
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 16
6. Regulation of synthesis of the transformation-induced protein, leukocyte plastin, by ovarian steroid hormones.
Leavitt, J. ; Chen, Z. P.; Lockwood, C. J.; Schatz, F.
JOURNAL NAME- Cancer Research
VOL. 54 NO. 13 1994 Jul 1 PP. 3447-54
CORPORATE AUTHOR- CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301
Citation references – 5
7. Activation of the leukocyte plastin gene occurs in most human cancer cells.
Park, T.; Chen, Z. P.; Leavitt, J.
JOURNAL NAME- Cancer Research
VOL. 54 NO. 7 1994 Apr 1 PP. 1775-81
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 20
8. Characterization of the human L-plastin gene promoter in normal and neoplastic cells.
Lin, C. S.; Chen, Z. P.; Park, T.; Ghosh, K.; Leavitt, J.
JOURNAL NAME- J Biol Chemistry
VOL. 268 NO. 4 1993 Feb 5 PP. 2793-801
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 38
9. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.
Lin, C. S.; Park, T.; Chen, Z. P.; Leavitt, J.
JOURNAL NAME- J Biol Chemistry
VOL. 268 NO. 4 1993 Feb 5 PP. 2781-92
CORPORATE AUTHOR- Laboratory of Cancer Cell Biology, Palo Alto Medical Foundation Research Institute, California 94301.
Citation references – 65
10. Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database.
Aebersold, R.; Leavitt, J.
JOURNAL NAME- Electrophoresis
VOL. 11 NO. 7 1990 Jul PP. 517-27
CORPORATE AUTHOR- Biomedical Research Centre, University of British Columbia, Vancouver, Canada.
Citation references – 54
de Arruda, M. V.; Watson, S.; Lin, C. S.; Leavitt, J. ; Matsudaira, P.
JOURNAL NAME- J Cell Biology
VOL. 111 NO. 3 1990 Sep PP. 1069-79
CORPORATE AUTHOR- Whitehead Institute for Biomedical Research, MIT, Cambridge, Massachusetts.
Citation references – 102
Lin, C. S.; Aebersold, R. H.; Leavitt, J.
JOURNAL NAME- Mol Cell Biology
VOL. 10 NO. 4 1990 Apr PP. 1818-21
CORPORATE AUTHOR- California Institute for Medical Research, San Jose 95128.
Citation references – 35
Lin, C. S.; Leavitt, J.
JOURNAL NAME- Mol Cell Biology
VOL. 8 NO. 1 1988 Jan PP. 160-8
CORPORATE AUTHOR- Linus Pauling Institute of Science and Medicine, Palo Alto, California 94306 Citation references – 31
Gunning, P.; Leavitt, J. ; Muscat, G.; Ng, S. Y.; Kedes, L.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 84 NO. 14 1987 Jul PP. 4831-5
CORPORATE AUTHOR- Dept. of Medicine, Stanford University, CA
Citation references – 801
Lin, C. S.; Aebersold, R. H.; Kent, S. B.; Varma, M.; Leavitt, J.
JOURNAL NAME- Mol Cell Biology
VOL. 8 NO.11 1988 Nov PP. 4659-68
DOCUMENT TYPE- JOURNAL ARTICLE
CORPORATE AUTHOR- California Institute for Medical Research, San Jose, California 95128.
Citation references – 75
Aebersold, R. H.; Leavitt, J. ; Saavedra, R. A.; Hood, L. E.; Kent, S. B.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 84 NO. 20 1987 Oct PP. 6970-4
DOCUMENT TYPE- JOURNAL ARTICLE
CORPORATE AUTHOR- Division of Biology, California Institute of Technology, Pasadena 91125.
Citation references – 745
Leavitt, J. ; Ng, S. Y.; Varma, M.; Latter, G.; Burbeck, S.; Gunning, P.; Kedes, L.
JOURNAL NAME- Mol Cell Biology
VOL. 7 NO. 7 1987 Jul PP. 2467-76
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA
Citation references – 58
Leavitt, J. ; Ng, S. Y.; Aebi, U.; Varma, M.; Latter, G.; Burbeck, S.; Kedes, L.; Gunning, P.
JOURNAL NAME- Mol Cell Biology
VOL. 7 NO. 7 1987 Jul PP. 2457-66
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA
Citation references – 68
Leavitt, J. ; Latter, G.; Lutomski, L.; Goldstein, D.; Burbeck, S.
JOURNAL NAME- Mol Cell Biology
VOL. 6 NO. 7 1986 Jul PP. 2721-6 CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA
Citation references – 79
20. Identification and order of sequential mutations in beta-actin genes isolated from increasingly tumorigenic human fibroblast strains.
Lin, C. S.; Ng, S. Y.; Gunning, P.; Kedes, L.; Leavitt, J.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 82 NO. 20 1985 Oct PP. 6995-9 DOCUMENT TYPE- JOURNAL ARTICLE
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 28
Ng, S. Y.; Gunning, P.; Eddy, R.; Ponte, P.; Leavitt, J. ; Shows, T.; Kedes, L.
JOURNAL NAME- Mol Cell Biol
VOL. 5 NO. 10 1985 Oct PP. 2720-32
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 411
Goldstein, D.; Djeu, J.; Latter, G.; Burbeck, S.; Leavitt, J.
JOURNAL NAME- Cancer Research
VOL. 45 NO. 11 Pt 2 1985 Nov PP. 5643-7
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 43
Leavitt, J. ; Gunning, P.; Kedes, L.; Jariwalla, R.
JOURNAL NAME- Nature
VOL. 316 NO. 6031 1985 Aug 29-Sep 4 PP. 840-2
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 114
Leavitt, J.
JOURNAL NAME- Carcinogenesis
VOL. 4 NO. 10 1983 Oct PP. 1229-37
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 8
Leavitt, J. ; Gunning, P.; Porreca, P.; Ng, S. Y.; Lin, C. S.; Kedes, L.
JOURNAL NAME- Mol Cell Biology
VOL. 4 NO. 10 1984 Oct PP. 1961-9
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 113
Latter, G. I.; Burbeck, S.; Fleming, J.; Leavitt, J.
JOURNAL NAME- Clinical Chemistry
VOL. 30 NO. 12 Pt 1 1984 Dec PP. 1925-32
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 34
27. Neoplastic human fibroblast proteins are related to epidermal growth factor precursor.
Burbeck, S.; Latter, G.; Metz, E.; Leavitt, J.
JOURNAL NAME- Proceedings Natl Acad Sci U S A
VOL. 81 NO. 17 1984 Sep PP. 5360-3
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 20
Leavitt, J. ; Bushar, G.; Kakunaga, T.; Hamada, H.; Hirakawa, T.; Goldman, D.; Merril, C.
JOURNAL NAME- Cell
VOL. 28 NO. 2 1982 Feb PP. 259-68
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 92
Leavitt, J. ; Goldman, D.; Merril, C.; Kakunaga, T.
JOURNAL NAME- Carcinogenesis
VOL. 3 NO. 1 1982 PP. 61-70
CORPORATE AUTHOR- Linus Pauling Institute, Palo Alto, CA 94306
Citation references – 37
Vandekerckhove, J.; Leavitt, J. ; Kakunaga, T.; Weber, K.
JOURNAL NAME- Cell
VOL. 22 NO. 3 1980 Dec PP. 893-9
DOCUMENT TYPE- Max-Planck Institute, Goettingen, Germany Citation references – 112
Leavitt, J. ; Leavitt, A.; Attallah, A. M.
JOURNAL NAME- J Biol Chemistry
VOL. 255 NO. 11 1980 Jun 10 PP. 4984-7
DOCUMENT TYPE- Bureau of Biologics, FDA, National Institutes of Health, Bethesda, MD
Citation references – 57
Leavitt, J. ; Kakunaga, T.
JOURNAL NAME- J Biol Chemistry
VOL. 255 NO. 4 1980 Feb 25 PP. 1650-61
DOCUMENT TYPE- Bureau of Biologics, FDA, National Institutes of Health, Bethesda, MD
Citation references – 130
THESIS – Doctor of Philosophy, Biochemistry “Stimulation of In-vitro RNA Synthesis by Ribosomes.” University of Pittsburgh, School of Medicine 1971. Sponsor – Kivie Moldave, Chairman of the Department of Biochemistry.
INVENTOR(S) LEAVITT, JOHN C .
PCT INT. APPL., AUG 04 1994, 66 PP.
PATENT NUMBER- 94 17182
PATENT APPLICATION NUMBER- 94-US436
DATE FILED- JAN 25 1994
DOCUMENT TYPE- PATENT
PATENT ASSIGNEE(S)- RESEARCH INSTITUTE OF THE PALO ALTO MEDICAL FOUNDATION
PATENT APPLICATION PRIORITY- 930126US9167
DESCRIPTOR(S)- PLASTIN PROMOTER PROGESTERONE ESTROGEN GENE EXPRESSION
INVENTOR(S)- Leavitt, John C .; Lin, Ching-Shwun; Aebersold, Ruedi H.
PATENT NUMBER- 05360715
PATENT APPLICATION NUMBER- 642983
DATE FILED- 1991-01-10
PATENT DATE- 1994-11-01
NUMBER OF CLAIMS- 16
PATENT CLASS- Invention (utility) patent
INVENTOR COUNTRY/ZIPCODE- .; .; CAX
PATENT ASSIGNEE(S)- California Institute of Technology
ASSIGNEE CITY- Pasadena CA
ATTORNEY, AGENT, OR FIRM- Skjerven, Morrill, MacPherson, Franklin & Friel
Plastin isoforms and their use
INVENTOR(S)- Leavitt, John C .; Lin, Ching-Shwun; Aebersold, Ruedi H.
PATENT NUMBER- 05002870
PATENT APPLICATION NUMBER- 495256
DATE FILED- 1990-03-16
PATENT DATE- 1991-03-26
NUMBER OF CLAIMS- 4
SUPPLEMENTARY NOTE(S)- 25611
PATENT CLASS- Invention (utility) patent
INVENTOR COUNTRY/ZIPCODE- .; .; CAX
PATENT ASSIGNEE(S)- California Institute for Medical Research
ASSIGNEE CITY- San Jose CA
ATTORNEY, AGENT, OR FIRM- Terlizzi, Laura
INVENTOR(S)- Leavitt, J. C. ; Kedes, L. H.; Gunning, P. W.
PATENT NUMBER- EP 0174608
PATENT DATE- 1986 19 Mar
DOCUMENT TYPE- Patent
CORPORATE AUTHOR- Leland Stanford Junior University, USA
PATENT PRIORITY INFO- Appl. US 650958, filed 13 Sep 1984
PATENT TYPE- European Patent Appl.
ATTORNEY, AGENT, OR FIRM- Bert Rowland
(licensed to the Biotech Industry 1985-2002)
